Academy_News_Towardpi

2024-11-28

Intraretinal “Bridge”, A RAP Revealed by 3D Full Range SS-OCTA!

Intraretinal “bridge”, a RAP revealed by 3D full range SS-OCTA! A 66-year-old female was found a round lesion at macular in her left eye because of blurred vision. High-resolution OCT B-scan showed local retinal detachment at macular with intraretinal hyperreflection connected to RPE close to fovea. “Double-layer sign” and RPE interruption were also observed (fig 1, yellow arrow). 6mm x 6mm full range OCTA was obtained centered fovea. The blood signal on avascular layer verified the existence of neovascularization. On B-scan image with blood signal overlayed, corresponding neovascularization was detected both inside the intraretinal hyperreflection lesion (fig 2, yellow arrow) and beneath RPE (fig 2, red arrow). This patient was diagnosed as retinal angiomatous proliferation (RAP) in her left eye. Retinal thickness in ETDRS rings and neovascularization area were quantified with build-in software for follow-up. 3D reconstruction showed how the neovascularization extended from deep vascular complex to beneath RPE (gif). TowardPi full range swept source OCT was used in this case to detect neovascularization. Numerous measurements and flow quantifications are available on the device. 3D structure and vessels can be easily obtained with build-in software. Case courtesy of: team from Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University Editor: Dr. Chloe Li, TowardPi Medical

2024-11-17

"Primary" or "Delayed"? IOL Tilt and Decentration Evaluated by Panoramic AS SS-OCT!

"Primary" or "delayed"? IOL tilt and decentration evaluated by panoramic AS SS-OCT! Research recently published in evaluated the tilt and decentration of intraocular lenses (IOLs) in eyes that underwent phacovitrectomy for macula-off rhegmatogenous retinal detachment (RRD) repair by using panoramic anterior segment (AS) swept source OCT. 63 patients with macula-off RRD who underwent phacovitrectomy were enrolled and divided into a primary implantation group and a delayed implantation group according to the time of IOL implantation. IOL tilt, measured as α angle—angle of the IOL axis (black line) and the pupillary axis (green line), and IOL decentration (red segment, distance between IOL center and the pupillary axis) were analyzed on the device (figure 1). Results showed that the absolute values of IOL tilt and decentration were greater in eyes with delayed IOL implantation than in eyes with primary implantation. Primary IOL implantation leads to a postoperative myopic shift, while in the delayed group, the extent of IOL tilt and decentration positively correlated with the time interval between phacovitrectomy and IOL implantation. A 100KHz speed full range swept source OCTA (#YAlkaid, TowardPi Medical) was used in this study to achieve panoramic AS OCT with 15mm scan depth, which makes it easy to visualize entire anterior segment from top of cornea to posterior lens capsule. All measurements are automatic assisted by AI technology on the device (figure 2). This research was authored by Dr. Qingchen Li from Shanghai Aier Eye Hospital, and Dr. Rui Liu from Shanghai Municipal Hospital of Traditional Chinese Medicine. Special appreciation for the suggestions and assistance given by Dr. Jian Zhou. Link to original text: https://lnkd.in/gqD4nePf

2024-11-01

Quantification of Subclinical Ocular Fundus Changes in SLE with Full-Range Swept-Source OCTA

The article recently published in Frontiers in Immunology focused on ocular fundus features, specifically within the retina and choroid, which can potentially help with early diagnosis, the prediction of systemic disease activity, and the involvement of other systems in SLE.

2024-10-28

Double Circulation Pattern in Amelanotic Choroidal Melanoma Revealed by 3D Full-Range SS-OCTA

A 54-year-old female patient with painless vision loss in her right eye was found to have a large circular yellowish-white intraocular mass with little pigmentation as shown in the color fundus image (A). Ophthalmic ultrasound showed an intraocular mushroom-shaped choroidal mass with abundant blood ﬂow. MRI revealed corresponding intraocular, oval, T1-isointense, and T2-hyperintense mass (C). UWF full-range OCTA clearly revealed vascular information in the tumor. A double circulation pattern between retinal and tumor vessels was shown by novel 3D OCTA, corresponding to the result of ﬂuorescein fundus angiography. A diagnosis of amelanotic choroidal melanoma was confirmed by histopathological examination.

2024-10-22

“Fireworks” in the Fundus Revealed by Ultra-Widefield Fundus Imaging

A 12-year-old boy presented with distorted vision in his left eye for 3 years was found bilateral, multiple, discrete, round, yellow-white, atrophic, punched-out spots and concentric chorioretinal streaks in the color fundus images (A and B, top).

2024-10-18

Choroidal Indicators for Pediatric Myopia Identified by UWF Full-Range SS-OCTA

New research, recently published in Photodiagnosis and Photodynamic Therapy, has measured the choroidal circulatory parameters in Han Chinese children aged 4–14 years with mild to moderate myopia. The study explored the relationships between these parameters, age, axial length (AL), and choroidal thickness (ChT) using UWF full-range SS-OCTA.

2024-10-11

Retinal Curvature in Pediatric Myopia: New TowardPi Publication in BJO

New research recently published in the British Journal of Ophthalmology quantitatively measured retinal curvature (RC) in children with myopia and explored its association with refractive status using UWF full-range SS-OCTA and an integrated three-dimensional (3D) reconstruction system on the device. Retinal curvature serves as a novel quantitative metric characterizing retinal steepness and provides new insights for deeper research into ocular morphology. Using integrated auto-segmentation and retinal reconstruction software based on UWF 24mm x 20mm OCTA scans, Bruch’s membrane was identified and isolated. Each point’s Gaussian curvature on Bruch’s membrane was calculated as RC according to axial length (AL) (fig).

2024-10-08

Retinal Thickness and Vessel Distribution in 4-to-16-Year-Old Myopic Children Using UWF SS-OCTA

This cross-sectional research, recently published in Photodiagnosis and Photodynamic Therapy, evaluated the characteristics of macular retinal vessel density and thickness in 228 children aged 4 to 16 years with myopia using UWF SS-OCTA. Flow and structural parameters in the ETDRS grid, including superficial retinal vessel density (SVD), deep retinal vessel density (DVD), inner retinal thickness (IRT), outer retinal thickness (ORT), and full retinal thickness (FRT) (see figs. B-G), were analyzed in 24 mm x 20 mm UWF full-range SS-OCTA images (see fig. A). Subjects were categorized into low myopia, moderate-to-high myopia, and non-myopia groups.

2024-09-29

Incontinentia Pigmenti in UWF Full-range SS-OCTA

A 32-year-old female presented with distorted and blurred vision in her right eye. 160° UWF full range SS-OCTA (montage of two 24mm x 20mm) revealed vascular dilation, tortuosity, and temporal vascular anastomoses (fig. A arrowheads) with extensive nonperfusion (fig. A asterisks) in both eyes. Incontinentia pigmenti was diagnosed based on abnormalities of retinal features, skin and teeth, and family history. Foveal retinoschisis due to vitreomacular traction by the posterior vitreous cortex was detected (fig. B arrows) by high-resolution 24mm B-scan in her right eye.

2024-08-30

Unveiling Therapeutic Agents for DR

New research recently published in International Immunopharmacology explores the therapeutic potential of flavopiridol for diabetic retinopathy (DR) by suppressing DDX58 activation. Mice with streptozotocin (STZ)-induced DR and oxygen-induced retinopathy (OIR) were used to assess the role of flavopiridol in mitigating inflammatory responses and neovascularization. Wide-field SS-OCTA imaging was performed, centered around the optic nerve. Mice treated with flavopiridol exhibited reduced apoptosis in retinal ganglion cells (RGC) (Fig. 1B, C) and reduced neovascularization (Fig. 2B, C) compared with untreated mice. Retinal thickness measurements revealed the efficacy of flavopiridol in ameliorating retinal thickness and structure (Fig. 1H). Full-range SS-OCTA revealed that flavopiridol significantly reduced both neovascular and avascular areas (Fig. 2F).