A new study 'Quantitative assessment of retinal vasculature changes in systemic lupus erythematosus using wide-field OCTA and the correlation with disease activity' was recently published in the "Frontiers in Immunology" by using a 400KHz SS-OCT BMizar from TowardPi Medical.

The results showed that UWF OCTA could effectively detect FAZ destruction, retinal vascular obstruction, non-perfusion area, and morphological abnormalities in patients with SLE. In patients without retinopathy, retinal superficial vessel density (SVD) in multiple areas, including temporal and inferior region, was significantly higher than that in the control group, proving that peripheral retinal changes could improve the disease diagnostic capability. Higher SVD also showed close correlation with disease activity.

A single capture of 24×20mm OCTA image could clearly reflect retinal vessel perfusion within 120° of the intraocular angle, which was of great importance in discovering the occult non-perfusion area and assessing the severity of retinopathy in patients with SLE. All OCT/OCTA parameters were generated automatically by in-built software.

This study was authored by Dr. Lihui Meng etc., team of Prof. Youxin Chen and Dr. Xinyu Zhao, from Peking Union Medical College Hospital.

Link to original text: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1340224/full