UWF Choroidal Changes in cCSC with MNV Investigated by Full-Range SS-OCTA！

Research published in the International Journal of Ophthalmology investigated the choroidal vascular index (CVI) and choroidal structural changes beyond the subfoveal area in eyes with chronic central serous chorioretinopathy (cCSC), comparing cases with and without macular neovascularization (MNV) using ultra-widefield (UWF) swept-source OCTA (SS-OCTA).

Ultra-widefield quantitative analysis showed that CVI in cCSC eyes with MNV was significantly lower than in eyes without MNV in most regions, except the superotemporal, superior, and temporal areas, while remaining higher than in normal controls. The mean age was also significantly higher in the group with MNV compared with the group without MNV. These pan-choroidal findings suggest a direct association between reduced choroidal vascular components and MNV pathogenesis, indicating that MNV-associated vascular remodeling may exacerbate pathological changes.

A 400 kHz swept-source OCTA system (BMizar, TowardPi Medical) was used in this study to provide a comprehensive assessment of choroidal vascular alterations. The device enables multiple choroidal quantifications—including choroidal vascular index (CVI) and choroidal vascular volume (CVV) across all vessel sizes—through built-in software based on AI-assisted segmentation algorithms. These capabilities provide compelling evidence supporting the pivotal role of choroidal ischemia in the development of MNV secondary to cCSC.

This research was authored by Dr. Xianggui Zhang and colleagues from the team led by Prof. Yanping Song at the General Hospital of the Central Theater Command.

Link to the original article: https://www.ijo.cn/gjyken/article/abstract/20250510