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• Time of issue：2025-01-07 14:45
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(Summary description)Two LHON cases revealed by full range SS-OCTA！ A 12-year-old boy was found severe optic nerve atrophy in his both eyes because of vision lost together with visual field defect especially the nasal part field of vision. Structural and flow analysis showed symmetrically thin nerve fiber layer on the temporal side in both eyes together with reduced flow density of peripapillary capillaries and enlarged optic disc area. GMA report revealed severe ganglion cell lost in both eyes. The flow density of nerve fiber layer at macular was also diffusely declined (figure 1). This boy was diagnosed as Leber hereditary optic neuropathy (LHON) by gene detection. The pathogenic gene locus was 14484. Another 23-year-old male LHON patient was found similar to this boy and pathogenic gene locus was 11778. The color fundus images showed pale optic discs and even severe nerve fiber atrophy. Structural and flow analysis revealed almost total loss of nerve fiber layer (figure 2). A 400kHz speed swept source OCTA (#BMizar, TowardPi Medical) and a 100kHz speed SS-OCTA (#YAlkaid, TowardPi Medical) were used in these two cases. Both devices can provide comprehensive structural, including optic disc and nerve fiber layer analysis and ganglion cell analysis, and flow analysis to the disc and macula of neuropathy based on high-resolution B-scan and precise segmentation algorithm. A progression analysis can be easily generated for disease management. Case courtesy of: Dr. Meng Chen and Dr. Haiyan Sun, team of Prof. Jihong Luo from Hubei University of Chinese Medicine. Editor: Dr. Chloe Li, TowardPi Medical