Academy_News_Towardpi

2025-01-04

Regulatory Mechanism of The Circadian Rhythm on CNV Revealed by Full Range SS-OCTA！

Regulatory mechanism of the circadian rhythm on CNV revealed by full range SS-OCTA！ Research recently published in < Biochemistry and Molecular Biology > investigated the regulatory mechanism of STRA6 in CNV under circadian rhythm disturbances via in vivo and in vitro animal study by using full range SS-OCTA. This study represented the first attempt to establish a connection between circadian rhythms and AMD. A circadian rhythm in VEGF expression was noted in this study that disturbed circadian rhythm might lead to a decrease during physiological conditions. STRA6 knockdown effectively mitigated the CNV promotion effect of circadian rhythm disturbance in mice and cell models. In vitro evidences suggested that STRA6 reduced CNV production by inhibiting JAK2/STAT3 phosphorylation after circadian rhythm disturbance. “All these results suggest that STRA6 may be a new direction for the treatment of AMD.” A 400kHz speed swept source OCTA (BMizar, TowardPi Medical) was used in this study to achieve OCT and OCTA images of mice. No additional lens is needed to capture animal eyes. The thickness, area and blood flow of CNV lesion were automatically quantified with built-in software on the device. This research is authored by Dr. Ying Yang, Dr. Shenglai Zhang, etc. team of Prof. Jia Chen and Prof. Aimin Sang, from Affiliated Hospital of Nantong University. Link to full text: https://lnkd.in/gjqMnHjE

2024-12-25

An Intraocular “Secret Eye” Revealed by UWF SS-OCT!

An intraocular “secret eye” revealed by UWF SS-OCT! Case report recently published in described a case of retinal detachment with a large retinal cystoid abnormality. A 400kHz speed full range swept source OCTA (BMizar, TowardPi Medical) was used in this case to easily achieve the high-resolution B-scan image of the detached peripheral retina. No retinal hole was found in this case. This case is authored by Dr. Yue Zhang and Dr. Qiang Liu, team of Prof. Xiaobing Yu, from Beijing Hospital. Original text link: https://lnkd.in/gssP7rec

2024-12-23

Retinal Vein Anastomoses Revealed by UWF SS-OCTA！

Retinal vein anastomoses revealed by UWF SS-OCTA！ The case report recently published in described a patient with retinal venous-venous anastomoses associated with persistent high IOP. A 400kHz speed full range swept source OCTA (#BMizar, TowardPi Medical) was used in this case to acquire high-resolution 24mm x 20mm UWF OCTA image of the abnormal vein anastomoses. 24mm UWF high-resolution B-scans were captured to follow up the change of choroidal thickness after treatment. This case is authored by Dr. Nan Luo, Dr. Yuzhou Xiang, team of Prof. Jingjing Huang from Zhongshan Ophthalmic Center, Sun Yat-sen University. Original text link: https://lnkd.in/gvBExJ_G #ophthalmology #SSOCT #medicaldevices

2024-12-22

Peripapillary Capillaries Changes in Myopia Revealed by UWF Full Range SS-OCTA！

Peripapillary Capillaries Changes in Myopia revealed by UWF full range SS-OCTA！ Research recently published in explored the effect of high myopia on peripapillary capillaries (RPCs) by using UWF full range SS-OCTA and analyzing superficial retina vascular density (SVD). By detecting the changes in peripheral SVD and the area of RPC, the results showed that high myopic individuals had significantly lower peripheral SVD and a smaller area of RPC corresponding to axial length and diopter. Early detecting the peripheral vasculature and structure might be beneficial in identifying some early changes in high myopia. And the area of RPC was proposed as a new biomarker for monitoring the progress of myopia. A 400kHz speed swept source OCTA (#BMizar, TowardPi Medical) was used in this study to achieve high-resolution 120° UWF OCTA images which can be used to detect peripheral retinal changes. Numerous vascular parameters, such as SVD, can be quantified in all sizes OCTA images with built-in software. This research is authored by Dr. Yishuang Xu, team of Prof. Zhen Chen and Prof. Dihao Hua, from Renmin Hospital of Wuhan University. Link to full text: https://lnkd.in/ggmft6t9

2024-12-20

Vortex Vein Drainage Systems in Healthy Individuals Imaged by UWF Full Range SS-OCTA！

Vortex vein drainage systems in healthy individuals imaged by UWF full range SS-OCTA！ New research recently published in investigated the choroidal characteristics of vortex vein (VV) drainage systems in healthy individuals by using ultra-widefield full range SS-OCTA. According to the results, one of the most significant characterizations of the VV drainage system identified was the superotemporal drainage system emerging as the preferential system in healthy eyes. The sex differences on perfusion in the VV drainage system was obvious. Higher CVI was observed for men compared to women. The occurrence of intervortex venous anastomosis, which is a common feature of pachychoroid spectrum disorders, was observed to be most frequent in the temporal quadrant. “The VV drainage system may be considered a promising biomarker for ocular diseases.” A 400kHz speed swept source OCTA (hashtag#BMizar, TowardPi Medical) was used in this study to achieve 24mmx20mm choroid OCTA with built-in AI-assisted algorithm. Five 24mmx20mm images can be intelligently montaged into a UWF choroid image (>200 degrees) automatically to visualize complete vortex vein ampullas in four quadrants. Quantification parameters of choroid OCTA, such as 3D-CVI, have high repeatability and accuracy based on precise segmentation algorithm. This research is authored by Dr. Zhonghua Luo, Dr. Xiaomei Xiong, Dr. Shengsong Huang, etc. team of Prof. Xiaoling Liang and Prof. Shanshan Yu, from Zhongshan Ophthalmic Center, Sun Yat-Sen University. Link to full text: https://lnkd.in/gQpxHTH3 hashtag#ophthalmology hashtag#SSOCT hashtag#medicaldevices

2024-12-17

Brand New Parameter Assessing Retinoschisis in High Myopia by UWF-SS-OCT!

Posterior Gaussian curvature -- brand new parameter assessing retinoschisis in high myopia by UWF-SS-OCT! Research recently published in evaluated macular retinoschisis and paravascular retinoschisis in high myopia and the relationship between existence of retinoschisis and posterior Gaussian curvature (K) by using UWF full Range SS-OCTA, authored by Dr. Qing Zhao, etc. team of Prof. Zhikun Yang, from Peking Union Medical College Hospital. The results showed that the largest Gaussian curvature was predominantly found in the posterior pole. Macular retinoschisis and higher maximum curvature value were significantly associated with the presence of paravascular retinoschisis. Longer axial length and higher Gaussian curvature could be high risk factors of whole retinoschisis. 'UWF-SS-OCT holds promise as an imaging technique for the early detection of extrafoveal retinoschisis.' A 400kHz speed full range swept source OCTA (#BMizar, TowardPi Medical) was used in this research to quantify the posterior Gaussian curvature (K) with built-in software on the device based on UWF 3D structural reconstruction. Original text link: https://lnkd.in/gRv2v44A

2024-11-28

Intraretinal “Bridge”, A RAP Revealed by 3D Full Range SS-OCTA!

Intraretinal “bridge”, a RAP revealed by 3D full range SS-OCTA! A 66-year-old female was found a round lesion at macular in her left eye because of blurred vision. High-resolution OCT B-scan showed local retinal detachment at macular with intraretinal hyperreflection connected to RPE close to fovea. “Double-layer sign” and RPE interruption were also observed (fig 1, yellow arrow). 6mm x 6mm full range OCTA was obtained centered fovea. The blood signal on avascular layer verified the existence of neovascularization. On B-scan image with blood signal overlayed, corresponding neovascularization was detected both inside the intraretinal hyperreflection lesion (fig 2, yellow arrow) and beneath RPE (fig 2, red arrow). This patient was diagnosed as retinal angiomatous proliferation (RAP) in her left eye. Retinal thickness in ETDRS rings and neovascularization area were quantified with build-in software for follow-up. 3D reconstruction showed how the neovascularization extended from deep vascular complex to beneath RPE (gif). TowardPi full range swept source OCT was used in this case to detect neovascularization. Numerous measurements and flow quantifications are available on the device. 3D structure and vessels can be easily obtained with build-in software. Case courtesy of: team from Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University Editor: Dr. Chloe Li, TowardPi Medical

2024-11-21

Novel Choroidal Biomarker in Predicting Treatment Outcomes of PCV: 3D CVI!

Novel choroidal biomarker in predicting treatment outcomes of PCV: 3D CVI! The research recently published in innovatively investigated the relationship between multiple choroidal biomarkers, clinical parameters, and the response to 3-monthly anti-VEGF therapy in PCV eyes by using full range SS-OCTA. 54 patients were enrolled and underwent a comprehensive ophthalmic examination at the initial visit and follow-up. Choroid thickness (CT) and 3D CVI (the ratio of the choroidal vessel volume to the total choroid volume) in 6mm x 6mm full range SS-OCTA centered on the fovea were analyzed. The result showed that the higher CVI at baseline was the ONLY factor that correlated with the poor response after 3 monthly injections of anti-VEGF and the CVI value showed superior predictive ability compared with the CT value. In the other word, 3D CVI using full range SS-OCTA was a promising biomarker to predict the response to anti-VEGF treatment in PCV patients. “This biomarker could also be a useful tool to identify the population at risk of an inadequate response to anti-VEGF.” A 400kHz speed full range swept source OCTA (BMizar, TowardPi Medical) was used in this research to detect neovascularization and quantify the choroid vasculature with built-in algorithms. Automatic segmentation of the choroidal Haller's and Sattler's layer and choroid parameters such as 3D CVI are available on the device. This study was authored by Dr. Yue Zhang, etc. team of Prof. Xiaobing Yu from Department of Ophthalmology, Beijing Hospital. Link to origin text: https://lnkd.in/gZ8tcaB9

2024-11-17

"Primary" or "Delayed"? IOL Tilt and Decentration Evaluated by Panoramic AS SS-OCT!

"Primary" or "delayed"? IOL tilt and decentration evaluated by panoramic AS SS-OCT! Research recently published in evaluated the tilt and decentration of intraocular lenses (IOLs) in eyes that underwent phacovitrectomy for macula-off rhegmatogenous retinal detachment (RRD) repair by using panoramic anterior segment (AS) swept source OCT. 63 patients with macula-off RRD who underwent phacovitrectomy were enrolled and divided into a primary implantation group and a delayed implantation group according to the time of IOL implantation. IOL tilt, measured as α angle—angle of the IOL axis (black line) and the pupillary axis (green line), and IOL decentration (red segment, distance between IOL center and the pupillary axis) were analyzed on the device (figure 1). Results showed that the absolute values of IOL tilt and decentration were greater in eyes with delayed IOL implantation than in eyes with primary implantation. Primary IOL implantation leads to a postoperative myopic shift, while in the delayed group, the extent of IOL tilt and decentration positively correlated with the time interval between phacovitrectomy and IOL implantation. A 100KHz speed full range swept source OCTA (#YAlkaid, TowardPi Medical) was used in this study to achieve panoramic AS OCT with 15mm scan depth, which makes it easy to visualize entire anterior segment from top of cornea to posterior lens capsule. All measurements are automatic assisted by AI technology on the device (figure 2). This research was authored by Dr. Qingchen Li from Shanghai Aier Eye Hospital, and Dr. Rui Liu from Shanghai Municipal Hospital of Traditional Chinese Medicine. Special appreciation for the suggestions and assistance given by Dr. Jian Zhou. Link to original text: https://lnkd.in/gqD4nePf

2024-11-01

Quantification of Subclinical Ocular Fundus Changes in SLE with Full-Range Swept-Source OCTA

The article recently published in Frontiers in Immunology focused on ocular fundus features, specifically within the retina and choroid, which can potentially help with early diagnosis, the prediction of systemic disease activity, and the involvement of other systems in SLE.