The new study recently published in "Nano Energy" (IF=17.6) presented a self-generated electricity-driven drug delivery system (EDDDS) (fig.1) designed for precision myopia treatment which can intelligently release therapeutic drugs, such as atropine, at ocular tissues using drug-coated nanogenerators. This system combined nanotechnology and smart drug delivery mechanisms to achieve controlled and responsive drug administration. Meanwhile, the weak voltage can effectively relieve the ciliary muscle, offering additional benefits for myopia management.

In vivo experiments with lens-induced myopia guinea pigs revealed a discernible increase in choroidal blood flow after the EDDDS treatment (fig.2).  ‘This significant augmentation not only stands as a testament to the therapeutic potential of our approach but also augured a promising avenue in the amelioration of myopia.’

A 400KHz speed full-range swept-source OCTA (BMizar, TowardPi Medical) was used in this research for evaluation of choroidal blood flow with in-built software. OCT and OCTA images of animal eyes can be captured without any extra lens by TowardPi BMizar. Axial length calibration is also available on the device.

This study was authored by Dr. Lingxi Jiang, Dr, Luhan Zhang, and others, the team of Prof. Yi Shi and Prof. Yang-Bao Miao from Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China and Prof. Zong-Hong Lin from Department of Biomedical Engineering, National Taiwan University.

Link to the original text: https://www.sciencedirect.com/science/article/pii/S2211285523008777