Central and Peripheral Changes Found in Both RVO Eyes and Unaffected Fellow Eyes

A study, recently published in <Investigative Ophthalmology & Visual Science>, aimed to explore the central and peripheral retinal and choroidal changes in retinal vein occlusion (RVO) and fellow eyes by using a 400kHz speed UWF full-range SS-OCTA BMizar from TowardPi Medical. Comprehensive retinal and choroidal parameters were directly analyzed by the device and compared between CRVO and BRVO patients, including unaffected fellow eyes, and healthy controls.

(VFD: retinal vessel flow density, VLD: vessel linear density, CVV: choroidal vascularity volume, CVI: choroidal vascularity index, LMCV-VFD: VFD in the large and medium choroidal vessels, AI: acircularity index)
Both ischemic CRVO and BRVO eyes showed FAZ enlargement and irregularity, decreased VFD, increased thickness, and increased volume in the central and/or peripheral retinal regions. Lower LMCV-VFD and CVI were observed in ischemic CRVO, ischemic CRVO fellow eyes, and BRVO eyes. The decreased CVI with unchanged CVV in RVO eyes may suggest the possibility of choroidal swelling or congestion affecting the stroma. The study also revealed notable decreased retinal VFD, increased retinal thickness and volume, increased LMCV-VFD, and decreased CVI in unaffected fellow eyes compared with normal controls, which gave support to the hypothesis that RVO might be indicative of broader systemic vascular changes affecting both eyes. The utilization of UWF SS-OCTA imaging allowed for the comprehensive visualization of both central and peripheral fundus regions in a single examination.

The study was authored by Dr. Xinyu Zhao and Dr. Qing Zhao etc., team of Prof. Youxin Chen, and Dr. Srinivas R. Sadda.
Link to original text:
https://iovs.arvojournals.org/article.aspx?articleid=2793341