Explore the diurnal variation of choroid among healthy people. The study recently published in "Translational Vision Science & Technology" evaluated the diurnal variation in choroidal parameters among healthy subjects and identified correlations between choroidal luminal area and stromal area and various systemic factors by using ultra-widefield full-range SS-OCTA. This study confirmed the existence of substantial diurnal variations in choroidal volume.
Measurements of choroidal parameters, including choroidal volume (CV), choroidal thickness (CT), choroidal vessel volume (CVV), and choroidal stromal volume (CSV) taken at 8:00, 12:00, 18:00, and 22:00 were analyzed across nine regions. The variations in choroidal volume across all nine regions were observed to correspond with total choroidal volume changes. Furthermore, fluctuations CV in the superiortemporal, superior nasal, temporal, nasal, inferior temporal, and inferior nasal regions had stronger associations with changes in CVV than with CSV in the corresponding regions, indicating that choroidal vessels might play a crucial role in these variations.
Interestingly, regarding total and regional choroidal parameters, significant diurnal variations were noticed. The mean total CT, CV, CVV, and CSV were at their lowest at 12:00 and peaking at 22:00 (fig.2). These findings aided our understanding of the choroid and potentially influencing how we approach choroidal diseases.
A 400KHz speed full range swept source OCTA (BMizar, TowardPimedical) was used in this study to quantify the choroidal volume and thickness based on the accurate segmentation of Sattler’s layer and Haller’s layer. Quantification analysis of choroidal vessels in 3D are provided on-device with in-built software, offering an efficient way to obtain reliable data without secondary processing steps.
This study was authored by Dr. Guiqin He, Dr. Xiongze Zhang, and others, the team of Prof. Feng Wen, from Zhongshan Ophthalmic Center, Sun Yat-Sen University.
Link to the original text: https://tvst.arvojournals.org/article.aspx?articleid=2793671
